Todd S. Perlstein, MD, MMsc

Todd S. Perlstein, MD, MMsc


Medical School – University of Arizona College of Medicine, Tucson, AZ

Residency – Emory University Hospitals, Atlanta, GA

Fellowship – Brigham and Women’s Hospital, Boston, MA

Specializing In

Cardiologist in Mesa and Gilbert, AZ

Dr. Todd S. Perlstein completed his training in Cardiovascular Medicine and Vascular Medicine at Brigham and Women’s Hospital, a Harvard Medical School affiliate. Dr. Perlstein served as an Instructor of Medicine at Harvard Medical School and an Associate Physician at Brigham and Women’s Hospital prior to joining Tri-City Cardiology. He completed his undergraduate degree in molecular and cellular biology and Medical Doctorate at the University of Arizona College of Medicine. Dr. Perlstein completed his Internship and Residency in Internal Medicine at Emory University School of Medicine, where he was selected to serve as Chief Medical Resident. He has also received a Master’s degree in Medical Science from Harvard Medical School.

Dr. Perlstein completed research fellowships in Hypertension and in Vascular Medicine at Brigham and Women’s Hospital and Harvard Medical School. He has performed original research investigating the development and treatment of cardiovascular disease. Dr. Perlstein’s work has been published in peer-reviewed scientific journals such as Circulation, Archives of Internal Medicine, Journal of Clinical Endocrinology and Metabolism, Kidney International, Hypertension, Journal of the American Society of Nephrology, Environmental Health Perspectives, Arteriosclerosis Thrombosis and Vascular Biology, The American Journal of Medicine, Blood, Thrombosis and Haemostasis, Clinical Science (London) and Nature.

Dr. Perlstein has contributed to the education of his peers and colleagues through both writing and speaking. He has written book chapters on the topics of stroke, carotid artery disease, Raynaud’s phenomenon, peripheral artery disease and non-coronary atherosclerotic vascular disease. He has spoken at educational conferences about the subjects of hypertension, diseases of the aorta, peripheral artery disease, carotid artery disease, hyperlipidemia and non-invasive vascular ultrasound.


  • Elected by his peers for inclusion in Best Doctors in America 1996-2016.
  • Chief Medical Resident for the Department of Medicine at the Emory University School of Medicine.
  • Recipient of the Eugene Braunwald Fellowship in Cardiovascular Medicine at Brigham and Women’s Hospital.
  • Winner of the Elizabeth Barrett-Connor Research Award in Epidemiology and Prevention for Investigators in Training, awarded by the American Heart Association’s Council on Epidemiology and Prevention.
  • Recipient of the American College of Cardiology-Foundation Cardiovascular Fellowship Research Award.


Original Research Published in Peer-Reviewed Journals

  • Gumieniak O, Perlstein TS, Hopkins PN, Brown NJ, Murphey LJ, Jeunemaitre X, Hollenberg NHK, Williams GH. Thyroid function and blood pressure homeostasis in euthyroid subjects. Journal of Clinical Endocrinology and Metabolism 2004;89:3455-61. PMID: 15240631.
  • Perlstein TS, Gumieniak O, Hopkins PN, Murphey LJ, Brown NJ, Williams GH, Hollenberg NHK, Fisher NDL. Uric acid and the state of the intrarenal renin-angiotensin system in humans.  Kidney International 2004;66:1465-70. PMID: 15458439.
  • Gumieniak O, Hurwitz S, Perlstein TS, Ngumezi UC, Hopkins PN, Jeunemaitre X, Williams GH.  Aggregation of high normal TSH in hypertensive families.  Journal of Clinical Endocrinology and Metabolism 2005;90(11):5985-90. PMID: 16091492.
  • Pojoga L, Kolatkar NS, Williams JS, Perlstein TS, Jeunemaitre X, Brown NJ, Hopkins PN, Raby BA, Williams GH. A beta-2 adrenergic receptor diplotype defines a subset of salt-sensitive hypertension. Hypertension 2006;48:892-900. PMID: 17015767.
  • Perlstein TS, Gumieniak O, Williams GH, Sparrow D, Vokonas PS, Gaziano M, Weiss ST, Litonjua AA. Uric acid and the development of hypertension: The Normative Aging Study. Hypertension 2006;48:1031-6. PMID: 17060508.
  • Gumieniak O, Perlstein TS, Hopkins PN, Brown NJ, Murphey LJ, Jeunemaitre X, Williams JS, Hollenberg NK, Williams GH. Ala92 type 2 deiodinase allele increases risk for the development of hypertension. Hypertension 2007;49:1-6. PMID: 17224473.
  • Perlstein TS, Gerhard-Herman M, Hollenberg NK, Williams GH, Thomas A.  Insulin induces renal vasodilation, increases plasma renin activity, and sensitizes the renal vasculature to angiotensin receptor blockade in healthy subjects.  Journal of the American Society of Nephrology 2007;18(3):944-51. PMID: 17287426.
  • Lewis RB, Adler GK, Perlstein TS, Seely EW, Hopkins PN, Williams GH, Garg R.  Body mass index predicts aldosterone production in normotensive adults on a high-salt diet. Journal of Clinical Endocrinology and Metabolism 2007;92(11):4472-5. PMID: 17726083.
  • Perlstein TS, Weuve J, Schwartz J, Sparrow D, Wright R, Litonjua AA, Nie H, Hu H. Cumulative community-level lead exposure and pulse pressure: The Normative Aging Study.  Environmental Health Perspectives 2007;115(12):1696-700. PMID: 18087585.
  • Pande RL, Perlstein TS, Beckman JA, Creager MA.  The association of insulin resistance and inflammation with peripheral arterial disease: the National Health and Nutrition Examination Survey 1999-2004. Circulation 2008;118(1):33-41.  PMID: 18559705.
  • Perlstein TS, Pande RL, Beckman JA, Creager MA. Serum total bilirubin level and prevalent lower extremity peripheral arterial disease: National Health and Nutrition Examination Survey (NHANES) 1999-2004. Arteriosclerosis Thrombosis and Vascular Biology 2008;28(1):166-72. PMID: 17975120.
  • Perlstein TS, Pande RL, Creager MA, Weuve J, Beckman JA. Serum total bilirubin level, prevalent stroke, and stroke outcomes: National Health and Nutrition Examination Survey 1999-2004.  The American Journal of Medicine 2008;121(9):781-8. PMID: 18724968.
  • Perlstein TS, Weuve J, Pfeffer MA, Beckman JA.  Red blood cell distribution width and mortality risk in a community-based prospective cohort.  Archives of Internal Medicine 2009;169(6):588-94. PMID:  19307522.
  • Peters JL, Perlstein TS, Perry MJ, McNeely E, Weuve J. Cadmium exposure in association with history of stroke and heart failure. Environmental Research 2010;110(2):199-206.PMID 20060521.
  • Pande RL, Park MA, Perlstein TS, Desai AS, Doyle J, Navarrete N, Copeland-Halperin RS, Redline W, Di Carli MF, Creager MA. Impaired skeletal muscle glucose uptake by [18F]fluorodeoxyglucose-positron emission tomography in patients with peripheral artery disease and intermittent claudication. Arterioscler Thromb Vasc Biol 2011;31(1):190-6. PMID: 21051665.
  • Perlstein TS, Pande RL, Berliner N, Vanasse GJ. Prevalence of 25-hydroxyvitamin D deficiency in subgroups of elderly persons with anemia: association with anemia of inflammation. Blood 2011;177:2800-6. PMID: 21239700.
  • Pande RL, Perlstein TS, Beckman JA, Creager MA. Secondary Prevention and Mortality in Peripheral Artery Disease: National Health and Nutrition Examination Survey 1999-2004. Circulation 2011;124(1):17-23. PMID: 21690489.
  • Perlstein TS, Goldhaber SZ, Nelson K, Joshi V, Morgan T Vance, Lesko LJ, Lee J-Y, Gobburu J, Schoenfeld D, Kucherlapati R, Freeman MW, Creager MA. The CReating an Optimal Warfarin Nomogram (CROWN) Study. Thrombosis and Haemostasis 2012;107(1):59-68. PMID: 22116191.
  • Perlstein TS, Henry RR, Mather KJ, Rickels MR, Abate NI, Grundy SM, Mai Y, Able JB, Marks JB, Pool JL, Creager MA. The Effect of Angiotensin Receptor Blockade on Insulin Sensitivity and Endothelial Function in Abdominally Obese Hypertensive Patients with Impaired Fasting Glucose. Clinical Science (London) 2012;122(4): 193-202. PMID: 21861845.
  • Steinhauser ML, Bailey A, Senyo SE, Guillermier C, Perlstein TS, Gould AP, Lee RT, Lechene CP. Multi-isotope imaging mass spectrometry quantifies stem cell division and metabolism. Nature 2012;481(7382):516-9. PMID: 22246326.

Educational Writing:

Review Articles:

  • Perlstein TS, Oestreicher EM, Adler GH.  A role for aldosterone in cardiovascular injury.  Current Opinion in Endocrinology, Diabetes & Obesity 2003;10(3):191-6.
  • Perlstein TS, Lee RT.  Smoking, metalloproteinases, and vascular disease.  Arteriosclerosis, Thrombosis, and Vascular Biology 2006;26(2):250-6. PMID: 16339501.

Case reports:

  • Gregory SA, Akutsu Y, Perlstein TS, Yasuda T, Yurchak PM. Inverted U waves.  Am J Med 2006; 119(9):746-7. PMID: 16945608.


  • Perlstein TS, Beckman JA.   Peri-operative cardiac biomarker surveillance: a strategy in need of a goal.  Vascular Medicine 2007;12(3):211-3. PMID: 17848479.
  • Perlstein TS, Creager MA. The ankle-brachial index as a biomarker of cardiovascular risk: It’s not just about the legs. Circulation 2009;120:2033-5. PMID: 19901185.

Book Chapters:

  • Perlstein TS. Hyponatremia. In: Doyle J, Martin L, editors. Case Studies in Ambulatory Medicine. Massachusetts: Lippincott, Williams, & Wilkins; 2001.
  • Perlstein TS, Krichavsky MZ. Peripheral Artery Disease. In: Antman E, Sabatine M, editors. Cardiovascular Therapeutics. Missouri: Elsevier, Inc; in press.
  • Creager MA, Perlstein TS, Halperin JL. Raynaud’s Phenomenon. In: Creager MA, Beckman JA, Loscalzo J. Vascular Medicine: A Companion to Braunwald’s Heart Disease. Philadelphia: Elsevier Inc. In press.
  • Perlstein TS, Creager MA. Epidemiology, Pathophysiology and Natural History of Atherosclerotic Peripheral Vascular Disease. In: Abrams’ Angiography: Interventional Radiology, 3rd Edition. In press.
  • Perlstein TS. Stroke Overview. In: O’Gara PT, Bashore TM, Fang JC, Hirsch GA, Indik JH, Polk DM, Rao SV. American College of Cardiology Self-Assessment Program, 8th Edition. 2012.
  • Perlstein TS. Extra-Cranial Carotid Disease. In: O’Gara PT, Bashore TM, Fang JC, Hirsch GA, Indik JH, Polk DM, Rao SV. American College of Cardiology Self-Assessment Program, 8th Edition. 2012.